NOF has developed novel degradable PEGs which have enzyme cleavable peptide moiety in the molecular structure. Degradable PEGs have the same blood circulation time as non-degradable PEGs and are removed from the body faster than non-degradable PEGs, because they are cleaved to lower molecular weight PEG in cell.
Proof of Concept
In vitro degradation test
GPC Chromatograms for Degradable PEG
Degradable PEGs in cells were completely degraded by intracellular enzymes.
Additionally, degradable PEGs were stable in the serum as same as non-degradable PEGs.
