Activated PEG Diacylglycerols

For site specific delivery, nanoparticles modified with ligands are widely used. Conventional modifying agents, like activated PEG-phospholipids, have a ionic-charge. It is not appreciate to apply them to lipid nanoparticles (LNP), because they have a negative impact on a charge and stability of LNP. Our “Activated PEG Diacylglycerol” has no charge, so it is useful for preparing site specific LNP.

Reference articles of targeting LNP :
1. T. Ishida et al., FEBS Letters, 1999, 460, 129-133.
2. C. Chen et al., International Journal of Nanomedicine, 2011, 6, 2567-2580.

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Chemical Name: 1,2-Distearoyl-rac-glycero-3-(succinimidyloxycarbonyl)polyoxyethylene
Chemical Name: 1,2-Distearoyl-rac-glycero-3-(2’-maleimidoethyl)polyoxyethylene
DSG-PEG-COO-NHS, PEG MW 3,400
DSG-PEG-COO-NHS, PEG MW 5,000
DSG-PEG-Maleimide, PEG MW 3,400
DSG-PEG-Maleimide, PEG MW 5,000
DSG-PEG-Azide, PEG MW 2,000
DSG-PEG-Azide, PEG MW 3,400
DSG-PEG-Azide, PEG MW 5,000
DSG-PEG-DBCO, PEG MW 2,000

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