Ultrapure Polysorbate 80


Polysorbate 80(HX2)™ produced by NOF CORPORATION is a ultrapure product of the highest quality in the world, with extremely low aldehyde and peroxide levels. These characteristics contribute to its safety; in a rat study, Polysorbate 80(HX2)™, as compared to conventional Polysorbate 80 formulations, triggered less histamine release from rat mast cells. The in vivo dog study has also indicated less histamine release with our Polysorbate 80(HX2); as a natural consequence, because of the lower incidence of allergy noted, our Polysorbate 80(HX2)™ has drawn worldwide attention.

Influence on Basophillic leukocyte

Basophilic leukocytes were immersed in 1% Polysorbate 80 solution for 30 min. The cells were immobilized in glutaraldehyde and observed by SEM.

Status of Chinese Pharmacopoeia (ChP)

Polysorbate 80 (HX2)™, is in compliance with “Polysorbate 80 (Ⅱ)” monograph of Chinese Pharmacopoeia.
NOF has submitted DMFs regarding our Polysorbate 80 (HX2)™ to NMPA China. (Registration numbers: F20190000324)