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Study Publication: Collaborative Research with University of Padova using NOF Y-shaped PEG Linkers
Tokyo, Japan — NOF CORPORATION is pleased to announce that a collaborative research paper featuring the company’s Y-shaped pendant-type monodisperse PEG linkers has been published in the International Journal of Biological Macromolecules (Volume 343, Part 2, February 2026, 150375).
https://doi.org/10.1016/j.ijbiomac.2026.150375
The study, titled “High-payload trastuzumab–drug conjugates achieved through hydrophilic Y-shaped pendant PEG linkers for a potent and selective antitumor response,” was led by Professor Gianfranco Pasut of the University of Padova, Italy, with researchers from NOF Corporation contributing as co-authors.
This research demonstrates that NOF’s Y-shaped pendant PEG linkers effectively mitigate the hydrophobicity associated with high drug payloads (DAR8), which typically compromise ADC stability. By identifying the PEG12 linker as the optimal lead, the study achieved a highly hydrophilic ADC with a prolonged pharmacokinetic profile and excellent tumor accumulation, resulting in near-complete tumor regression in vivo. These findings highlight the potential of the pendant-type monodisperse PEG in advancing the development of potent, high-payload next-generation therapeutics.
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