COATSOME CL-8181TA (DODAP)
Acronym: DOTAP
Chemical Name: 1,2-Dioleoyloxy-3-trimethylammonium propane chloride
CAS#: 132172-61-3
Molecular weight: 698.5
Alkyl composition: R1COO= C18:1, R2COO= C18:1
DODAP is an ionizable lipid for nucleic acid delivery in lipid nanoparticles (LNP) and liposomal formulations, remaining neutral under physiological conditions and acquiring a positive charge in the acidic environment of endosomes.