COATSOME SS-OP
COATSOME SS-OP is a specially designed ionizable lipid that plays a pivotal role in lipid nanoparticle (LNP)-based drug delivery systems and offers exceptional performance in encapsulating and delivering nucleic acid therapeutics such as mRNA, siRNA, and pDNA. It features dual-responsive motifs: tertiary amines that destabilize membranes in acidic environments like endosomes, and disulfide bond that can be cleaved under the reductive conditions of the cytoplasm. These two units synergize for efficient intracellular nucleic acid delivery of encapsulated drugs, leading to enhanced biosafety. Additionally, SS-OP contains phenyl ester bonds, which accelerate its degradation within the intracellular environment, improving delivery efficiency and reducing toxicity.
Key Features:
Reliable Encapsulation: Provides high encapsulation efficiency for nucleic acids in LNP drug delivery systems, ensuring stability and protection against enzymatic degradation.
Efficient Drug Delivery: Offers efficient delivery into the cytoplasm of cells and higher mRNA expression with lower toxicity compared to benchmark LNP formulations.
Proven Safety: In vivo studies demonstrate reduced hepatotoxicity, showing promising potential for clinical use
Versatile Applications: Suitable for a wide range of therapeutic areas, including gene editing, mRNA vaccines, cancer immunotherapy, and other gene therapies where efficient nucleic acid delivery is crucial.
These features position SS-OP as a promising component in advanced drug delivery systems, particularly for gene therapy and vaccine applications.