SUNBRIGHT GM-020EX
DMG-PEG2000
Chemical Name: 1,2-Dimyristoyl-rac-glycerol, methoxypolyethylene Glycol
CAS#:
PEG chain Molecular weight: 2000
Alkyl composition: R1COO= C14:0, R2COO= C14:0
SUNBRIGHT GM-020EX is an extremely high-purity PEG lipid (commonly known as DMG-PEG2000) designed to enhance the stability and efficiency of lipid nanoparticle (LNP) drug delivery systems. It features two C14:0 fatty acids (myristic acid) connected at the 1- and 2-positions of a glycerol backbone, and a polyethylene glycol (PEG) chain of 2,000 Da linked at the 3-position. By incorporating polyethylene glycol (PEG) into the surface of LNPs, it improves the stability and circulation time of LNPs in the bloodstream, facilitating efficient delivery of encapsulated therapeutic agents such as mRNA, siRNA, and other nucleic acids.
GM-020EX is a key component in LNP formulations to improve the delivery and performance of nucleic acid-based therapies. This type of PEG lipid (DMG-PEG2000) has been adopted in a COVID-19 mRNA vaccine.