SUNBRIGHT® GS-034TS

DSG-PEG-COO-NHS, PEG MW 3,400
Chemical Name: 1,2-Distearoyl-rac-glycero-3-(succinimidyloxycarbonyl) polyoxyethylene
CAS#: 3079792-07-4
RCOO= C18:0

For site-specific delivery, lipid nanoparticles (LNPs) modified with targeting ligands are widely used in advanced drug delivery systems. SUNBRIGHT GS-034TS is a functionalized PEG lipid designed for efficient ligand conjugation in LNP formulations. It features two C18:0 fatty acids (stearic acid) connected at the 1- and 2-positions of a glycerol backbone, with a 3,400 Da polyethylene glycol (PEG) chain at the 3-position, terminated with an NHS carbonate group. The NHS carbonate group enables conjugation with amine-containing molecules to form a stable carbamate bond. GS-034TS does not have a charge that could adversely affect the stability of LNPs, and is useful for developing active targeting delivery systems.