SUNBRIGHT® GS-050DB2

DSG-PEG-DBCO, PEG MW 5,000
Chemical Name: 1,2-Distearoyl-rac-glycero-3-{(3’-azadibenzocyclooctyne-3’-oxopropyl)aminocarbonyl} polyoxyethylene
CAS#:
RCOO= C18:0

For site-specific delivery, lipid nanoparticles (LNPs) modified with targeting ligands are widely used in advanced drug delivery systems. SUNBRIGHT GS-050DB2 is a functionalized PEG lipid designed for efficient ligand conjugation in LNP formulations. It features two C18:0 fatty acids (stearic acid) connected at the 1- and 2-positions of a glycerol backbone, with a 5,000 Da polyethylene glycol (PEG) chain at the 3-position, terminated with a DBCO group. The DBCO group enables site-specific conjugation with azide-containing molecules (such as peptides, antibodies, or other ligands) through copper-free click chemistry, forming a stable triazole linkage. This facilitates precise cellular targeting and enhances formulation versatility. GS-050DB2 does not have a charge that could adversely affect the stability of LNPs and is useful for developing active targeting delivery systems.